OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU

Kevin Mikael Rosales-Cruzalegui; Luis Enrique Polo-Vidal; Hugo Aurelio Alpaca-Salvador

doi:10.25176/RFMH.v26i2.7978

OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU

Kevin Mikael Rosales-Cruzalegui
, Luis Enrique Polo-Vidal
, Hugo Aurelio Alpaca-Salvador

Universidad Nacional del Santa

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: The association between the implementation of an Antimicrobial Stewardship Program (ASP) and clinical cure was evaluated in hospitalized patients with urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. A retrospective cohort study was conducted at Hospital III EsSalud-Chimbote, including a cohort of 18 patients not exposed to the ASP and 34 exposed patients. The overall clinical cure rate was 86.5%. In the multivariable model using Firth's penalized logistic regression, the ASP was not associated with clinical cure, with an adjusted odds ratio (aOR) of 0.37 (95% CI: 0.03–2.35; p=0.309). Female sex was associated with a higher likelihood of clinical cure, with an aOR of 7.32 (95% CI: 1.39–51.96; p=0.019). In conclusion, exposure to the ASP was not significantly associated with clinical cure in hospitalized patients with UTI caused by ESBL-producing E. coli.

Original language	English
Pages (from-to)	123-131
Number of pages	9
Journal	Revista de la Facultad de Medicina Humana
Volume	26
Issue number	2
DOIs	https://doi.org/10.25176/RFMH.v26i2.7978
State	Published - 30 Jun 2026

Bibliographical note

Publisher Copyright:
Article published by the Revista de la Facultad de Medicina Humana of Universidad Ricardo Palma. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), which allows non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited. For commercial use, please contact [email protected]

Keywords

Antimicrobial stewardship
Beta-lactamases
cohort studies
Escherichia coli infections
Urinary tract infections

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10.25176/RFMH.v26i2.7978

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title = "OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU",

abstract = "Introduction: The association between the implementation of an Antimicrobial Stewardship Program (ASP) and clinical cure was evaluated in hospitalized patients with urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. A retrospective cohort study was conducted at Hospital III EsSalud-Chimbote, including a cohort of 18 patients not exposed to the ASP and 34 exposed patients. The overall clinical cure rate was 86.5\%. In the multivariable model using Firth's penalized logistic regression, the ASP was not associated with clinical cure, with an adjusted odds ratio (aOR) of 0.37 (95\% CI: 0.03{\textendash}2.35; p=0.309). Female sex was associated with a higher likelihood of clinical cure, with an aOR of 7.32 (95\% CI: 1.39{\textendash}51.96; p=0.019). In conclusion, exposure to the ASP was not significantly associated with clinical cure in hospitalized patients with UTI caused by ESBL-producing E. coli.",

keywords = "Antimicrobial stewardship, Beta-lactamases, cohort studies, Escherichia coli infections, Urinary tract infections",

author = "Rosales-Cruzalegui, \{Kevin Mikael\} and Polo-Vidal, \{Luis Enrique\} and Alpaca-Salvador, \{Hugo Aurelio\}",

note = "Publisher Copyright: Article published by the Revista de la Facultad de Medicina Humana of Universidad Ricardo Palma. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), which allows non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited. For commercial use, please contact [email protected]",

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pages = "123--131",

journal = "Revista de la Facultad de Medicina Humana",

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OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU. / Rosales-Cruzalegui, Kevin Mikael; Polo-Vidal, Luis Enrique; Alpaca-Salvador, Hugo Aurelio.
In: Revista de la Facultad de Medicina Humana, Vol. 26, No. 2, 30.06.2026, p. 123-131.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU

AU - Rosales-Cruzalegui, Kevin Mikael

AU - Polo-Vidal, Luis Enrique

AU - Alpaca-Salvador, Hugo Aurelio

N1 - Publisher Copyright: Article published by the Revista de la Facultad de Medicina Humana of Universidad Ricardo Palma. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), which allows non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited. For commercial use, please contact [email protected]

PY - 2026/6/30

Y1 - 2026/6/30

N2 - Introduction: The association between the implementation of an Antimicrobial Stewardship Program (ASP) and clinical cure was evaluated in hospitalized patients with urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. A retrospective cohort study was conducted at Hospital III EsSalud-Chimbote, including a cohort of 18 patients not exposed to the ASP and 34 exposed patients. The overall clinical cure rate was 86.5%. In the multivariable model using Firth's penalized logistic regression, the ASP was not associated with clinical cure, with an adjusted odds ratio (aOR) of 0.37 (95% CI: 0.03–2.35; p=0.309). Female sex was associated with a higher likelihood of clinical cure, with an aOR of 7.32 (95% CI: 1.39–51.96; p=0.019). In conclusion, exposure to the ASP was not significantly associated with clinical cure in hospitalized patients with UTI caused by ESBL-producing E. coli.

AB - Introduction: The association between the implementation of an Antimicrobial Stewardship Program (ASP) and clinical cure was evaluated in hospitalized patients with urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. A retrospective cohort study was conducted at Hospital III EsSalud-Chimbote, including a cohort of 18 patients not exposed to the ASP and 34 exposed patients. The overall clinical cure rate was 86.5%. In the multivariable model using Firth's penalized logistic regression, the ASP was not associated with clinical cure, with an adjusted odds ratio (aOR) of 0.37 (95% CI: 0.03–2.35; p=0.309). Female sex was associated with a higher likelihood of clinical cure, with an aOR of 7.32 (95% CI: 1.39–51.96; p=0.019). In conclusion, exposure to the ASP was not significantly associated with clinical cure in hospitalized patients with UTI caused by ESBL-producing E. coli.

KW - Antimicrobial stewardship

KW - Beta-lactamases

KW - cohort studies

KW - Escherichia coli infections

KW - Urinary tract infections

UR - https://www.scopus.com/pages/publications/105046021240

U2 - 10.25176/RFMH.v26i2.7978

DO - 10.25176/RFMH.v26i2.7978

M3 - Artículo

AN - SCOPUS:105046021240

SN - 1814-5469

VL - 26

SP - 123

EP - 131

JO - Revista de la Facultad de Medicina Humana

JF - Revista de la Facultad de Medicina Humana

IS - 2

ER -

OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU

Abstract

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Keywords

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